Fixed-Dose Combination Therapy (Polypill) for the Prevention of Cardiovascular Disease
نویسندگان
چکیده
منابع مشابه
Fixed-dose combination therapy for the prevention of cardiovascular disease.
This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the effectiveness of fixed-dose combination therapy on optimising CVD risk factors and reducing CVD fatal and non-fatal events for both primary and secondary prevention of CVD. Details of CVD events and risk factors included are listed in the methods. We will also determine any adverse events...
متن کاملPolypill (fixed-dose combination) in the prevention of cardiovascular disease: rationale and clinical data
Cardiovascular diseases (CVDs) continue to be major contributors of death and disability globally. Control of CVD risk factors has been shown to be effective in reducing morbidity and mortality both in primary and secondary prevention settings. Given the cumulative benefits of concurrently controlling multiple CVD risk factors (high blood pressure, dyslipidemia and platelet activity) in individ...
متن کاملThe polypill in the primary prevention of cardiovascular disease.
Coronary heart disease (CHD) and stroke are the most common causes of death worldwide. The polypill, a multi-component tablet or capsule designed to reduce several cardiovascular causal risk factors simultaneously, has the potential to reduce the incidence of heart attacks and stroke by about 80%, the precise reduction depending on the formulation of the polypill and adherence to preventive tre...
متن کاملFixed-dose combination Therapy in Hypertension: Focus on Fixed-dose combination of Amlodipine and Valsartan (exforge®)
Hypertension is the leading cause of disability and cardiovascular mortality world-wide. Approximately one-third of the US adult population and over a billion people world-wide have hypertension. Despite increased awareness of hypertension and availability of many effective antihypertensive agents, only one third of patients achieve their target blood pressure (BP). All expert panels now recomm...
متن کاملA pilot double-blind randomised placebo-controlled trial of the effects of fixed-dose combination therapy ('polypill') on cardiovascular risk factors.
AIM Our objective was to investigate the effects and tolerability of fixed-dose combination therapy on blood pressure and LDL in adults without elevated blood pressure or lipid levels. METHODS This was a double-blind randomised placebo-controlled trial in residents of Kalaleh, Golestan, Iran. Following an 8-week placebo run-in period, 475 participants, aged 50 to 79 years, without cardiovascu...
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ژورنال
عنوان ژورنال: JAMA
سال: 2014
ISSN: 0098-7484
DOI: 10.1001/jama.2014.13616